In Pandemic, players take on distinct roles like Medic or Scientist to research cures for the blue, yellow, black, and red diseases threatening humanity.

By placing the shuffled discard pile back on top of the infection deck, Epidemic cards guarantee that previously hit cities will be drawn again to cause outbreaks.

A common beginner mistake is trying to eradicate every disease cube from the board, but the game ends in victory the exact moment the final cure is researched.

To create a permanent, evolving storyline, Pandemic Legacy requires players to alter the board with stickers and physically tear up specific playing cards.